About the vacancy
Oncology & Hematology
Immunology
About Your Next Job
We are looking for an enthusiastic and capable intern to join our immuno-oncology (IO) team. In the IO team we test novel immune therapies, from chemical activators to antibody dependent cell cytotoxicity and cellular therapies such as CAR-T. Thanks to our comprehensive biobank we are able to test these therapies using organoid models from many different cancer indications in 3D co-cultures with various types of immune cells.
The goal of this R&D project is to test and validate clinically approved combination treatments for various indications. These will be tested mainly by high-content imaging, to quantify organoid killing and proliferation/infiltration of the immune cells, as well as cytokine analysis of the supernatants.
In addition to knowledge of immunology and cellular biology, the candidate has to be creative, dedicated and responsible, and possess good analytical and problem-solving skills. You will be trained and guided through our IO assays and be part of the team, collaborating with and learning from us but also from other teams within the company. You will attend meetings, and also support other projects and general lab tasks. This will allow you to get acquainted with all the different parts of the work that is done in the team and in the company.
The internship is expected to start in May-July 2026 and to last for around 9 months.
About Your Tasks and Responsibilities
Responsibilities:
- Perform wet lab work
- Generate reports of the results
- Support the team in general lab tasks and in customer or internal R&D projects
About Your Skills and Experience
Requirements:
- Bachelor/master in cell biology, oncology, and/or immunology
- Familiar with cell culture, ideally with organoid technology
- Familiar with imaging and image analysis is a plus
- Proficient in English
- Legal resident of the European Union
- Eager to keep up with the field and continuously learn
Techniques:
- PBMC isolation, activation, and staining
- Flow cytometry
- Organoid culture and seeding
- Co-cultures of organoids and PBMCs
- High-throughput fluorescence imaging and luminescence
- Image and data analysis
- Immunocytochemistry
You are eligible to work in EU
We only accept applicants who are eligible to work in the EU
Contact person
Marit de Vries
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Crown Bioscience is a leading preclinical pharmacology CRO with a large collection of tumor models including cell lines, organoids, xenograft and homograft mouse tumor models, and provides drug testing services to pharmaceutical and biotech companies globally.
Over the years Crown Bioscience, has extensively profiled tumor models for their genomics, pharmacology and histopathology.
The site in Leiden focusses on high throughput imaging to assess compound activity in organoids, thereby contributing to the discovery of novel cancer therapeutics in the preclinical phase.